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Título: | Effects of angiotensin (1-7) upon right ventricular function in experimental rat pulmonary embolism |
Fecha de publicación: | 2011 |
Editorial: | F. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología. |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | 61 - Medicina |
Palabras clave: | Renin-angiotensin system Pulmonary embolism |
Resumen: | Right ventricular (RV) dysfunction contributes to poor clinical prognosis after pulmonary embolism (PE). The present studies evaluate the effects of angiotensin (1-7) (ANG (1-7)) upon RV function during experimental PE in rats. Circulating ANG II increased 8-fold 6 hr after PE (47±13 PE vs. 6±3 pg/mL, control, p<0.05). ACE2 protein was uniformly localized in the RV myocardium of control rats, but showed a patchy distribution with some cells devoid of stain after 6 or 18 hr of PE. RV function decreased 18 hr after PE compared with control treated animals (19±4 vs. 41±1 mmHg, respectively, p<0.05; 669±98 vs. 1354±77 mmHg/sec, respectively, p<0.05), while left ventricular function (LV) was not significantly changed. Animals treated with ANG (1-7) during PE showed improved RV +dP/dt and peak systolic pressure development to values not significantly different from control animals. Protection of RV function by ANG (1-7) was associated with improved arterial blood sO2, base excess and pH. Supplemental delivery of ANG (1-7) reduced the development of RV dysfunction, suggesting a novel approach to protecting RV function in the setting of acute experimental PE. |
Autor/es principal/es: | Watts, John A. Gellar, Michael A. Lori, Stuart Obraztsova, Maria Marchick, Michael R. Kline, Jeffrey A. |
Forma parte de: | Histology and histopathology, Vol. 26, nº10 (2011) |
URI: | http://hdl.handle.net/10201/49444 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.26,nº10 (2011) |
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Fichero | Descripción | Tamaño | Formato | |
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Watts-26-1287-1294-2011.pdf | 1,35 MB | Adobe PDF | Visualizar/Abrir |
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