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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Watts, John A. | - |
dc.contributor.author | Gellar, Michael A. | - |
dc.contributor.author | Lori, Stuart | - |
dc.contributor.author | Obraztsova, Maria | - |
dc.contributor.author | Marchick, Michael R. | - |
dc.contributor.author | Kline, Jeffrey A. | - |
dc.date.accessioned | 2016-04-29T14:19:39Z | - |
dc.date.available | 2016-04-29T14:19:39Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/49444 | - |
dc.description.abstract | Right ventricular (RV) dysfunction contributes to poor clinical prognosis after pulmonary embolism (PE). The present studies evaluate the effects of angiotensin (1-7) (ANG (1-7)) upon RV function during experimental PE in rats. Circulating ANG II increased 8-fold 6 hr after PE (47±13 PE vs. 6±3 pg/mL, control, p<0.05). ACE2 protein was uniformly localized in the RV myocardium of control rats, but showed a patchy distribution with some cells devoid of stain after 6 or 18 hr of PE. RV function decreased 18 hr after PE compared with control treated animals (19±4 vs. 41±1 mmHg, respectively, p<0.05; 669±98 vs. 1354±77 mmHg/sec, respectively, p<0.05), while left ventricular function (LV) was not significantly changed. Animals treated with ANG (1-7) during PE showed improved RV +dP/dt and peak systolic pressure development to values not significantly different from control animals. Protection of RV function by ANG (1-7) was associated with improved arterial blood sO2, base excess and pH. Supplemental delivery of ANG (1-7) reduced the development of RV dysfunction, suggesting a novel approach to protecting RV function in the setting of acute experimental PE. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología. | es |
dc.relation.ispartof | Histology and histopathology, Vol. 26, nº10 (2011) | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Renin-angiotensin system | es |
dc.subject | Pulmonary embolism | es |
dc.subject.other | 61 - Medicina | es |
dc.title | Effects of angiotensin (1-7) upon right ventricular function in experimental rat pulmonary embolism | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.26,nº10 (2011) |
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Watts-26-1287-1294-2011.pdf | 1,35 MB | Adobe PDF | Visualizar/Abrir |
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