Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10201/48281
Twittear
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Spina, Donatella | - |
dc.contributor.author | Ambrosio, Maria Raffaella | - |
dc.contributor.author | Rocca, Bruno Jim | - |
dc.contributor.author | Di Mari, Nicoletta | - |
dc.contributor.author | Onorati, Mónica | - |
dc.contributor.author | Luzzi, Luca | - |
dc.contributor.author | Monciatti, Irene | - |
dc.contributor.author | Tosi, Piero | - |
dc.date.accessioned | 2016-03-08T17:29:18Z | - |
dc.date.available | 2016-03-08T17:29:18Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/48281 | - |
dc.description.abstract | An association between rheumatoid arthritis (RA) and malignancies has been ascertained and patients with RA appear to be at higher risk of lymphoma and lung cancer. The higher risk of the latter malignancy may be related to rheumatoid interstitial lung disease and immunosuppressive therapies. Herein we illustrate the case of a 59-year-old male smoker affected by RA and treated with cortisone, methotrexate and TNF-α antagonists, who underwent right lower lobectomy for a nodular lesion. On microscopic examination, the lesion consisted of two distinct areas: a central area of fibrinoid necrosis, bordered by histiocytes in a palisaded arrangement, lymphocytes and a 0.4 cm thick peripheral area constituted by a combined small cell anaplastic carcinoma, adenocarcinoma and squamous cell carcinoma. The combination of three histotypes is very rare in such a small tumour. In our case, it may be hypothesized that synchronous, heterogeneous mutations occurred in different type of committed cells or in stem cells, due to the production of cytokines by RA nodule histiocytes and lymphocytes, which are contiguous to the carcinomatous area. Since few studies have evaluated the topographic correlation between tumors and rheumatoid lung lesions, further morphological and molecular studies are needed to clarify this association and the pathogenetic relationship between RA and cancer of the lung. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 | es |
dc.language | eng | es |
dc.publisher | Murcia: F. Hernández | es |
dc.relation.ispartof | Histology and histopathology, Vol. 26, nº 3 (2011) | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Rheumatoid arthritis | es |
dc.subject | Interstitial pneumonia | es |
dc.subject.other | 616 - Patología. Medicina clínica. Oncología | es |
dc.title | Rheumatoid nodule and combined pulmonary carcinoma: topographic correlations; a case report and review of the literature | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.26, nº3 (2011) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Spina-26-351-356-2011.pdf | 10,63 MB | Adobe PDF | Visualizar/Abrir |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.