Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10201/48275
Twittear
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Aresu, L. | - |
dc.contributor.author | Benali, S. | - |
dc.contributor.author | Garbisa, S. | - |
dc.contributor.author | Gallo, E. | - |
dc.contributor.author | Castagnaro, M. | - |
dc.date.accessioned | 2016-03-08T16:42:44Z | - |
dc.date.available | 2016-03-08T16:42:44Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/48275 | - |
dc.description.abstract | Tubular cell epithelial-mesenchymal transition (EMT) is a fundamental contributor to renal fibrosis. The aim of this study was to investigate the activity of different matrix metalloproteinases by immunohistochemistry and gel-zymography in a model of chronic canine kidney disease. Immunohistochemistry for antibodies against MMP-9, MMP-2, MMP-13, MMP-14 and TIMP-2 was performed on 28 renal biopsy specimens. Selected cases were chosen for gelatin zymography. In moderate and severe tubulo-interstitial damage, increased expression of MMP-2 was noted. A peculiar staining pattern for MMP-2 in variable-sized vesicles, corresponding to the area of basement membrane splitting, was observed. The immunoexpression of MMP-9 and TIMP-2 was reduced in the same cases, compared to control dogs. The splitting of the membrane suggests an active role of this gelatinase in the disruption of type-IV collagen, the main basement membrane component, confirmed by MMP2 gelatinolytic activity by gel-zymography. These data could provide the basis for clinical trials examining the potential benefits of selective MMP-2 inhibitors in dogs with chronic kidney disease. | es |
dc.format | application/pdf | es |
dc.format.extent | 7 | es |
dc.language | eng | es |
dc.publisher | Murcia: F. Hernández | es |
dc.relation.ispartof | Histology and histopathology, Vol. 26, nº 3 (2011) | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Fibrosis | es |
dc.subject | Zymography | es |
dc.subject.other | 636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticos | es |
dc.title | Matrix metalloproteinases and their role in the renal epithelial mesenchymal transition | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.26, nº3 (2011) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Aresu-26-307-313-2011.pdf | 1,73 MB | Adobe PDF | Visualizar/Abrir |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.