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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Canavese, M. | - |
dc.contributor.author | Altruda, F. | - |
dc.contributor.author | Silengo, L. | - |
dc.contributor.author | Castiglioni, V. | - |
dc.contributor.author | Scanziani, E. | - |
dc.contributor.author | Radaelli, E. | - |
dc.date.accessioned | 2016-03-08T16:24:01Z | - |
dc.date.available | 2016-03-08T16:24:01Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/48273 | - |
dc.description.abstract | Up-regulation of vascular endothelial growth factor (VEGF) plays a primary role in the pathogenesis of psoriasis. Transgenic mice over-expressing VEGF under the Keratin 14 (K14) promoter develop an inflammatory skin condition with many of the pathobiological features of human psoriasis. In this work, the development of spontaneous psoriatic-like dermatitis in K14-VEGF transgenic mice was monitored from week 6 to week 44 and skin lesions were characterized clinically (application of a clinical score system comparable to the human Psoriasis Area and Severity Index), microscopically (histopathology, leukocyte subset and neoangiogensis) and immunologically (evaluation of local and systemic cytokine/chemokine profiles). Based on PASI score system, three progressive clinical phases were identified: mild acute (8-14 weeks of age), moderate subacute (15-21 weeks of age) and severe chronic-active (22-44 weeks of age) dermatitis. Microscopically, skin lesions consisted of progressive proliferative psoriatic-like dermatitis dominated by dermo-epidermal infiltrates of CD3-positive lymphocytes, an increased number of mast cells and neoangiogenesis. Both local and systemic up-regulation of pro-inflammatory (IL-12, TNF-alpha, IL-6, MCP-1 and IL-8) and regulatory (IL-10) cytokines/chemokines was observed, mainly during the later stages of disease development. The results obtained in this study further confirm the central role of VEGF over-expression in the development of psoriatic-like dermatitis. Similarly to what is reported for human psoriasis, both the local and systemic immunologic profiles observed in K14-VEGF transgenic mice suggest that a combined Th1 and Th17 response may be implicated in lesion development. The identification of three progressive stages of disease, each with peculiar clinicopathological features, renders the K14-VEGF transgenic mouse a valuable model to study novel immunotherapies for psoriasis. | es |
dc.format | application/pdf | es |
dc.format.extent | 12 | es |
dc.language | eng | es |
dc.publisher | Murcia: F. Hernández | es |
dc.relation.ispartof | Histology and histopathology, Vol. 26, nº 3 (2011) | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Angiogenesis | en_EN |
dc.subject | Animal disease | en_EN |
dc.subject.other | 636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticos | es |
dc.title | Clinical, pathological and immunological features of psoriatic-like lesions affecting keratin 14-vascular endothelial growth factor transgenic mice | en_EN |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.26, nº3 (2011) |
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Fichero | Descripción | Tamaño | Formato | |
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Canavese-26-285-296-2011.pdf | 2,14 MB | Adobe PDF | Visualizar/Abrir |
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