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Título: | Dynorphin expression, processing and receptors in the alveolar macrophages, cancer cells and bronchial epithelium of lung cancer patients |
Fecha de publicación: | 2010 |
Editorial: | Murcia: F. Hernández |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | 616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Opioid peptides Carboxypeptidase |
Resumen: | Functional evidence suggests that opioid peptides such as dynorphin are involved in the regulation of airway macrophage functions and of human cancer growth. However, anatomical evidence for components of a putative dynorphin network within lung cancer patients is scarce. Tissue from lung cancer patients was examined immunohistochemically for all components of a local dynorphin (DYN) network. Double immunofluorescence microscopy analysis revealed colocalization of the opioid precursor PDYN with its end-product DYN, and key processing enzymes prohormone convertases 1 and 2 and carboxypeptidase E, as well as the kappa-opioid receptor (KOR) within alveolar macrophages and cancerous cells in varying degrees among patients. Moreover, chromograninAimmunoreactive pulmonary neuroendocrine cells expressing DYN were close to substance P- and KORimmunoreactive sensory nerves. Our findings give a first hint of a neuroanatomical basis for a peripheral DYN network, conceivably regulating pulmonary, immune and cell-proliferative functions within the human lung, most likely in a paracrine/autocrine fashion. |
Autor/es principal/es: | Mousa, Shaaban A. Krajnik, Malgorzata Sobanski, Piotr Kowalewski, Janusz Bloch-Boguslawska, Elzbieta Zylicz, Zbigniew Schafer, Michael |
Forma parte de: | Histology and histopathology, Vol. 25, nº 6 (2010) |
URI: | http://hdl.handle.net/10201/46510 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.25, nº6 (2010) |
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Fichero | Descripción | Tamaño | Formato | |
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Dynorphin expression, processing and.pdf | 3,63 MB | Adobe PDF | Visualizar/Abrir |
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