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http://hdl.handle.net/10201/46510
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Mousa, Shaaban A. | - |
dc.contributor.author | Krajnik, Malgorzata | - |
dc.contributor.author | Sobanski, Piotr | - |
dc.contributor.author | Kowalewski, Janusz | - |
dc.contributor.author | Bloch-Boguslawska, Elzbieta | - |
dc.contributor.author | Zylicz, Zbigniew | - |
dc.contributor.author | Schafer, Michael | - |
dc.date.accessioned | 2015-10-06T14:49:29Z | - |
dc.date.available | 2015-10-06T14:49:29Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/46510 | - |
dc.description.abstract | Functional evidence suggests that opioid peptides such as dynorphin are involved in the regulation of airway macrophage functions and of human cancer growth. However, anatomical evidence for components of a putative dynorphin network within lung cancer patients is scarce. Tissue from lung cancer patients was examined immunohistochemically for all components of a local dynorphin (DYN) network. Double immunofluorescence microscopy analysis revealed colocalization of the opioid precursor PDYN with its end-product DYN, and key processing enzymes prohormone convertases 1 and 2 and carboxypeptidase E, as well as the kappa-opioid receptor (KOR) within alveolar macrophages and cancerous cells in varying degrees among patients. Moreover, chromograninAimmunoreactive pulmonary neuroendocrine cells expressing DYN were close to substance P- and KORimmunoreactive sensory nerves. Our findings give a first hint of a neuroanatomical basis for a peripheral DYN network, conceivably regulating pulmonary, immune and cell-proliferative functions within the human lung, most likely in a paracrine/autocrine fashion. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Murcia: F. Hernández | es |
dc.relation.ispartof | Histology and histopathology, Vol. 25, nº 6 (2010) | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Opioid peptides | es |
dc.subject | Carboxypeptidase | es |
dc.subject.other | 616 - Patología. Medicina clínica. Oncología | es |
dc.title | Dynorphin expression, processing and receptors in the alveolar macrophages, cancer cells and bronchial epithelium of lung cancer patients | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.25, nº6 (2010) |
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Dynorphin expression, processing and.pdf | 3,63 MB | Adobe PDF | ![]() Visualizar/Abrir |
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