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Título: | Cytoplasmic inclusions of TDP-43 in neurodegenerative diseases: A potential role for caspases |
Fecha de publicación: | 2009 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 57 - Biología |
Palabras clave: | Alzheimer’s disease Hirano Bodies |
Resumen: | TAR DNA-binding protein-43 (TDP-43) proteinopathies are classified based upon the extent of modified TDP-43 inclusions and include a growing number of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with ubiquitin immunoreactive, tau negative inclusions (FTLD-U) and FTLD with motor neuron disease (FTLD-MND). In addition, TDP-43 inclusions have also been identified in a number of other neurodegenerative disorders including Alzheimer’s disease, corticobasal degeneration, Lewy body related diseases and Pick’s disease. Current understanding suggests that in these diseases, TDP-43 is relocated from the nucleus to the cytoplasm and sequestered into inclusions that contain modified TDP-43. Major modifications of TDP-43 have been identified as being hyperphosphorylation and proteolytic cleavage by caspases. In this review a summary of the major findings regarding the proteolytic modification of TDP-43 will be discussed as well as potential toxic-gain mechanisms these fragments may cause including cytoskeletal disruptions. |
Autor/es principal/es: | Rohn, Troy T. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/36060 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.24, nº8 (2009) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Cytoplasmic inclusions of TDP43 in neurodegenerative Cytoplasmic inclusions of TDP43 in neurodegenerative.pdf | 3,12 MB | Adobe PDF | Visualizar/Abrir |
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