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Título: Intestinal uptake of amyloid B protein through columnar epithelial cells in suckling mice
Fecha de publicación: 2009
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: 636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticos
Palabras clave: Amyloidosis
Columnar epithelial cells
Resumen: The mechanism of transmission of amyloid protein, especially the dynamics in the intestine, is still largely unknown. In the present study, a fusion protein (Aß-EGFP) that combined enhanced green fluorescent protein with amyloid-ß protein (Aß) was orally administered to mice before and after weaning, and the uptake and kinetics of amyloid protein within the intestine were elucidated through histopathology. Aß- EGFP was incorporated into the cytoplasm of columnar epithelial cells, rather than M cells, at 3 h after administration and thereafter. Aß-EGFP then accumulated in the crypt, Peyer's patch, and even the spleen. However, this uptake was not observed in weaned mice. These results suggest that a specific tolerant mechanism for incorporation of Aß escaped from the digestion exists during suckling periods. This age-dependent uptake is important for estimating the risk of transmission.
Autor/es principal/es: Ano, Yasuhisa
Nakayama, Hiroyuki
Sakudo, Akikazu
Sawano, Yoriko
Tanokura, Masaru
Itohara, Shigeyoshi
Onodera, Takashi
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/35999
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 10
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.24, nº3 (2009)

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