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Título: | Intestinal uptake of amyloid B protein through columnar epithelial cells in suckling mice |
Fecha de publicación: | 2009 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticos |
Palabras clave: | Amyloidosis Columnar epithelial cells |
Resumen: | The mechanism of transmission of amyloid protein, especially the dynamics in the intestine, is still largely unknown. In the present study, a fusion protein (Aß-EGFP) that combined enhanced green fluorescent protein with amyloid-ß protein (Aß) was orally administered to mice before and after weaning, and the uptake and kinetics of amyloid protein within the intestine were elucidated through histopathology. Aß- EGFP was incorporated into the cytoplasm of columnar epithelial cells, rather than M cells, at 3 h after administration and thereafter. Aß-EGFP then accumulated in the crypt, Peyer's patch, and even the spleen. However, this uptake was not observed in weaned mice. These results suggest that a specific tolerant mechanism for incorporation of Aß escaped from the digestion exists during suckling periods. This age-dependent uptake is important for estimating the risk of transmission. |
Autor/es principal/es: | Ano, Yasuhisa Nakayama, Hiroyuki Sakudo, Akikazu Sawano, Yoriko Tanokura, Masaru Itohara, Shigeyoshi Onodera, Takashi |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/35999 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.24, nº3 (2009) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Intestinal uptake of amyloid B protein through columnar epithelial cells in suckling mice.pdf | 3,22 MB | Adobe PDF | Visualizar/Abrir |
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