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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Ano, Yasuhisa | es |
dc.contributor.author | Nakayama, Hiroyuki | es |
dc.contributor.author | Sakudo, Akikazu | - |
dc.contributor.author | Sawano, Yoriko | - |
dc.contributor.author | Tanokura, Masaru | - |
dc.contributor.author | Itohara, Shigeyoshi | - |
dc.contributor.author | Onodera, Takashi | - |
dc.date.accessioned | 2013-09-24T11:33:50Z | - |
dc.date.available | 2013-09-24T11:33:50Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/35999 | - |
dc.description.abstract | The mechanism of transmission of amyloid protein, especially the dynamics in the intestine, is still largely unknown. In the present study, a fusion protein (Aß-EGFP) that combined enhanced green fluorescent protein with amyloid-ß protein (Aß) was orally administered to mice before and after weaning, and the uptake and kinetics of amyloid protein within the intestine were elucidated through histopathology. Aß- EGFP was incorporated into the cytoplasm of columnar epithelial cells, rather than M cells, at 3 h after administration and thereafter. Aß-EGFP then accumulated in the crypt, Peyer's patch, and even the spleen. However, this uptake was not observed in weaned mice. These results suggest that a specific tolerant mechanism for incorporation of Aß escaped from the digestion exists during suckling periods. This age-dependent uptake is important for estimating the risk of transmission. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | en_EN |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Amyloidosis | en_EN |
dc.subject | Columnar epithelial cells | en_EN |
dc.subject.other | 636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticos | es |
dc.title | Intestinal uptake of amyloid B protein through columnar epithelial cells in suckling mice | en_EN |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.24, nº3 (2009) |
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Fichero | Descripción | Tamaño | Formato | |
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Intestinal uptake of amyloid B protein through columnar epithelial cells in suckling mice.pdf | 3,22 MB | Adobe PDF | Visualizar/Abrir |
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