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Título: | Expression of claudin-2 in the multistage process of gastric carcinogenesis |
Fecha de publicación: | 2008 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 616.3 - Patología del aparato digestivo. Odontología |
Palabras clave: | Immunohistochemistry Gastric cancer |
Resumen: | Objective: Claudin-2 is an important component of the tight junction (TJ) of epithelial cells, and its protein expression between many tumours is significantly different. It is unclear if Claudin-2 overexpression is a trigger or a consequence during carcinogenesis. The multistage tissues of gastric carcinogenesis provides us a valuable model for determining tumourigenicity. Methods: This paper investigated, for the first time, claudin-2 expression in the pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy. To determine claudin-2 expression in gastric carcinogenesis by immunochemical ABC technique. Results: Altogether, 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples were analyzed. Results indicated that the percentage of claudin-2-positive cases was 0% for chronic superficial gastritis (0/108), 0% for chronic atrophic gastritis (0/55), 0% for intestinal-type metaplasia (0/109), 35.87% for dysplasia (33/92), and 73.47% for gastric intestinal-type adenocarcinoma (36/49) respectively, primarily in the cell membrane, and gradually increased in the multistage process of gastric carcinogenesis (P<0.001). Conclusions: This suggests that claudin-2 protein overexpression may be closely correlated to gastric carcinogenesis. |
Autor/es principal/es: | Song, X. Li, X. Tang, Y. Chen, H. Wong, B. Wang, J. Chen, M. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/29816 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.23, nº6 (2008) |
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Fichero | Descripción | Tamaño | Formato | |
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Expression of claudin-2 in the multistage process of gastric carcinogenesis.pdf | 15,34 MB | Adobe PDF | Visualizar/Abrir |
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