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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Song, X. | es |
dc.contributor.author | Li, X. | es |
dc.contributor.author | Tang, Y. | - |
dc.contributor.author | Chen, H. | - |
dc.contributor.author | Wong, B. | - |
dc.contributor.author | Wang, J. | - |
dc.contributor.author | Chen, M. | - |
dc.date.accessioned | 2013-01-22T10:01:50Z | - |
dc.date.available | 2013-01-22T10:01:50Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/29816 | - |
dc.description.abstract | Objective: Claudin-2 is an important component of the tight junction (TJ) of epithelial cells, and its protein expression between many tumours is significantly different. It is unclear if Claudin-2 overexpression is a trigger or a consequence during carcinogenesis. The multistage tissues of gastric carcinogenesis provides us a valuable model for determining tumourigenicity. Methods: This paper investigated, for the first time, claudin-2 expression in the pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy. To determine claudin-2 expression in gastric carcinogenesis by immunochemical ABC technique. Results: Altogether, 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples were analyzed. Results indicated that the percentage of claudin-2-positive cases was 0% for chronic superficial gastritis (0/108), 0% for chronic atrophic gastritis (0/55), 0% for intestinal-type metaplasia (0/109), 35.87% for dysplasia (33/92), and 73.47% for gastric intestinal-type adenocarcinoma (36/49) respectively, primarily in the cell membrane, and gradually increased in the multistage process of gastric carcinogenesis (P<0.001). Conclusions: This suggests that claudin-2 protein overexpression may be closely correlated to gastric carcinogenesis. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Immunohistochemistry | es |
dc.subject | Gastric cancer | es |
dc.subject.other | 616.3 - Patología del aparato digestivo. Odontología | es |
dc.title | Expression of claudin-2 in the multistage process of gastric carcinogenesis | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.23, nº6 (2008) |
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Fichero | Descripción | Tamaño | Formato | |
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Expression of claudin-2 in the multistage process of gastric carcinogenesis.pdf | 15,34 MB | Adobe PDF | Visualizar/Abrir |
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