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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Hildenbrand, Ralf | es |
dc.contributor.author | Gandhari, Mukesh | es |
dc.contributor.author | Stroebel, Philipp | - |
dc.contributor.author | Marx, Alexander | - |
dc.contributor.author | Allgayer, Heike | - |
dc.contributor.author | Arens, Norbert | - |
dc.date.accessioned | 2013-01-22T09:59:39Z | - |
dc.date.available | 2013-01-22T09:59:39Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/29792 | - |
dc.description.abstract | The serine protease urokinase-type plasminogen activator (uPA) and its receptor (uPAR) are involved in the control of extracellular matrix turnover, cell migration, invasion and cell signalling leading to a variety of different responses, under both physiological and pathological conditions. The urokinase receptor, binding to the growth factor-like domain of uPA, directs membrane-associated extracellular proteolysis and signals through transmembrane proteins, thus regulating tissue regeneration, angiogenesis, cancer growth and metastasis. Since these physiological and pathophysiological processes of the uPA-system are known, less informations concerning uPA-induced cell proliferation and anti-apoptotic effects of the uPAsystem are available. Recent studies show a close relationship of the uPA-system and cell proliferation/ apoptosis. uPA is responsible for the activation and release of different growth factors and modulates the cell proliferation/apoptosis ratio through the dynamic control of cell-matrix interactions. This article focuses on the important role of the uPA/uPAR-system for cell proliferation and apoptosis. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Urokinase | es |
dc.subject | Cell proliferation | es |
dc.subject.other | 616 - Patología. Medicina clínica. Oncología | es |
dc.title | The urokinase-system - role of cell proliferation and apoptosis | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.23, nº2 (2008) |
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Fichero | Descripción | Tamaño | Formato | |
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The urokinase-system - role of cell proliferation and apoptosis.pdf | 406,5 kB | Adobe PDF | Visualizar/Abrir |
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