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dc.contributor.authorHildenbrand, Ralfes
dc.contributor.authorGandhari, Mukeshes
dc.contributor.authorStroebel, Philipp-
dc.contributor.authorMarx, Alexander-
dc.contributor.authorAllgayer, Heike-
dc.contributor.authorArens, Norbert-
dc.date.accessioned2013-01-22T09:59:39Z-
dc.date.available2013-01-22T09:59:39Z-
dc.date.issued2008-
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/29792-
dc.description.abstractThe serine protease urokinase-type plasminogen activator (uPA) and its receptor (uPAR) are involved in the control of extracellular matrix turnover, cell migration, invasion and cell signalling leading to a variety of different responses, under both physiological and pathological conditions. The urokinase receptor, binding to the growth factor-like domain of uPA, directs membrane-associated extracellular proteolysis and signals through transmembrane proteins, thus regulating tissue regeneration, angiogenesis, cancer growth and metastasis. Since these physiological and pathophysiological processes of the uPA-system are known, less informations concerning uPA-induced cell proliferation and anti-apoptotic effects of the uPAsystem are available. Recent studies show a close relationship of the uPA-system and cell proliferation/ apoptosis. uPA is responsible for the activation and release of different growth factors and modulates the cell proliferation/apoptosis ratio through the dynamic control of cell-matrix interactions. This article focuses on the important role of the uPA/uPAR-system for cell proliferation and apoptosis.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectUrokinasees
dc.subjectCell proliferationes
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleThe urokinase-system - role of cell proliferation and apoptosises
dc.typeinfo:eu-repo/semantics/articlees
Aparece en las colecciones:Vol.23, nº2 (2008)

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