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Título: | The function of actin in gene transcription |
Fecha de publicación: | 2007 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 577 - Bioquímica. Biología molecular. Biofísica |
Palabras clave: | Nuclear actin Ribonucleoproteins |
Resumen: | Recent developments in the field of gene transcription regulation have unfolded a key role for actin as an important co-factor for all three eukaryotic RNA polymerases. In this review article we discuss the latest findings on actin in transcription of protein-coding and ribosomal genes, in complex with specific hnRNP proteins and a form of myosin 1ß which is entirely localized to the cell nucleus. Based on these recent studies, we propose a general model where actin may function in basal gene transcription as an allosteric regulator, to recruit transcriptional co-activators on active genes. A future challenge will be the identification of the polymerization state of actin in gene transcription and how it is mechanistically regulated. |
Autor/es principal/es: | Obrdlik, A. Kukalev, A. Percipalle, P. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/27633 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 5 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.22, nº 9 (2007) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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The function of actin in gene transcription.pdf | 496,56 kB | Adobe PDF | Visualizar/Abrir |
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