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Título: | Expression of AGR2 in non small cell lung cancer |
Fecha de publicación: | 2007 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Lung cancer Immunohistochemistry |
Resumen: | We aimed to evaluate immunohistochemically the expression of the human Anterior Gradient-2 (AGR2), a gene which has recently been proposed as an oncogene for lung carcinoma development, in non small cell lung cancer and to correlate the findings to clinico-pathological data including patient survival. 95 cases of NSCLC were immunostained using a polyclonal AGR2 antibody and statistical analyses were applied to test for prognostic and diagnostic associations. AGR2 was expressed in 66.3% of cases, preferentially adenocarcinomas. There were no relevant associations with clinico-pathological paramaters. A prognostic value of AGR2 could not be demonstrated neither in multivariate nor in univariate analyses. Interestingly, this is the first study to demonstrate AGR2 expression in squamous cell carcinomas. Although a prognostic value of AGR2 seems unlikely further studies are warranted to investigate the biological role of AGR2 in NSCLC and its differential expression according to histology. |
Autor/es principal/es: | Fritzsche, F.R. Dahl, E. Dankof, A. Burkhardt, M. Pahl, S. Petersen, I. Dietel, Manfred Kristiansen, Gitte |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/27610 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.22, nº 7 (2007) |
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Fichero | Descripción | Tamaño | Formato | |
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Expression of AGR2 in non small cell lung cancer.pdf | 2,28 MB | Adobe PDF | Visualizar/Abrir |
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