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Título: | Down regulation of gastric and intestinal phenotypic expression in Epstein-Barr virus-associated stomach cancers |
Fecha de publicación: | 2007 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 616.3 - Patología del aparato digestivo. Odontología |
Palabras clave: | Stomach cancers Epstein-Barr virus |
Resumen: | importance of gastric and intestinal phenotypic expression for stomach carcinogenesis. In this study, we focused on Epstein-Barr virus (EBV)-associated stomach cancers, with special attention to Cdx2. Methods and Results: We evaluated the expression of gastric and intestinal phenotypic markers by immunohistochemistry in 35 EBV-positive [EBV (+)] and 75 EBV-negative [EBV (-)] stomach cancers in Colombia. The lesions were divided phenotypically into gastric (G), gastric-and-intestinal mixed (GI), intestinal (I), and null (N) phenotypes. In the EBV (+) cases, the lesions were divided phenotypically into 9 G (25.7%), 1 GI (2.9%), 3 I (8.6%), and 22 N (62.9%) types. Similarly, the EBV (-) lesions were also classified phenotypically as 15 G (20.0%), 19 GI (25.3%), 24 I (32.0%), and 17 N (22.7%) types. The proportion of N type EBV (+) lesions was higher than for their EBV (-) counterparts (P<0.0001). The expression of Cdx2 and MUC2 was also found to be significantly lower in EBV (+) than in EBV (-) stomach cancers (P=0.0001; P<0.0001). Cdx2 expression in the intestinal metaplastic glands present in non-neoplastic mucosa surrounding EBV (+) lesions was also significantly lower than in EBV (-) tumors (P=0.016) despite no evidence of EBV infection by low expression of intestinal phenotype markers, including Cdx2, and only occasional gastric phenotypic expression. |
Autor/es principal/es: | Hirano, N. Tsukamoto, T. Mizoshita, T. Koriyama, C. Akiba, S. Campos, F. Carrasquilla, G. Carrascal Marino, E. Cao, X. Toyoda, T. Ban, H. Miki, K. Tatematsu, M. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/27597 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.22, nº 6 (2007) |
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Down regulation of gastric and intestinal phenotypic expression in EpsteinBarr virusassociated stomach cancers.pdf | 686,53 kB | Adobe PDF | Visualizar/Abrir |
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