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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Hirano, N. | es |
dc.contributor.author | Tsukamoto, T. | es |
dc.contributor.author | Mizoshita, T. | - |
dc.contributor.author | Koriyama, C. | - |
dc.contributor.author | Akiba, S. | - |
dc.contributor.author | Campos, F. | - |
dc.contributor.author | Carrasquilla, G. | - |
dc.contributor.author | Carrascal Marino, E. | - |
dc.contributor.author | Cao, X. | - |
dc.contributor.author | Toyoda, T. | - |
dc.contributor.author | Ban, H. | - |
dc.contributor.author | Miki, K. | - |
dc.contributor.author | Tatematsu, M. | - |
dc.date.accessioned | 2012-05-21T12:09:53Z | - |
dc.date.available | 2012-05-21T12:09:53Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/27597 | - |
dc.description.abstract | importance of gastric and intestinal phenotypic expression for stomach carcinogenesis. In this study, we focused on Epstein-Barr virus (EBV)-associated stomach cancers, with special attention to Cdx2. Methods and Results: We evaluated the expression of gastric and intestinal phenotypic markers by immunohistochemistry in 35 EBV-positive [EBV (+)] and 75 EBV-negative [EBV (-)] stomach cancers in Colombia. The lesions were divided phenotypically into gastric (G), gastric-and-intestinal mixed (GI), intestinal (I), and null (N) phenotypes. In the EBV (+) cases, the lesions were divided phenotypically into 9 G (25.7%), 1 GI (2.9%), 3 I (8.6%), and 22 N (62.9%) types. Similarly, the EBV (-) lesions were also classified phenotypically as 15 G (20.0%), 19 GI (25.3%), 24 I (32.0%), and 17 N (22.7%) types. The proportion of N type EBV (+) lesions was higher than for their EBV (-) counterparts (P<0.0001). The expression of Cdx2 and MUC2 was also found to be significantly lower in EBV (+) than in EBV (-) stomach cancers (P=0.0001; P<0.0001). Cdx2 expression in the intestinal metaplastic glands present in non-neoplastic mucosa surrounding EBV (+) lesions was also significantly lower than in EBV (-) tumors (P=0.016) despite no evidence of EBV infection by low expression of intestinal phenotype markers, including Cdx2, and only occasional gastric phenotypic expression. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Stomach cancers | es |
dc.subject | Epstein-Barr virus | es |
dc.subject.other | 616.3 - Patología del aparato digestivo. Odontología | es |
dc.title | Down regulation of gastric and intestinal phenotypic expression in Epstein-Barr virus-associated stomach cancers | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.22, nº 6 (2007) |
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Down regulation of gastric and intestinal phenotypic expression in EpsteinBarr virusassociated stomach cancers.pdf | 686,53 kB | Adobe PDF | Visualizar/Abrir |
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