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Título: | Gastric and intestinal phenotypic correlation between exocrine and endocrine components in human stomach tumors |
Fecha de publicación: | 2007 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 616.3 - Patología del aparato digestivo. Odontología |
Palabras clave: | Stomach cancers Endocrine cells |
Resumen: | We have previously suggested that an origin of a stomach cancer is from a progenitor cell specializing toward exocrine cell (Exo-cell) lineages. To clarify whether our hypothesis is correct or not, we analyzed the expression of Exo-cell and endocrine cell (End-cell) markers in a series of lesions for comparison. We evaluated chromogranin A (CgA) expression in 37 early and 73 advanced stomach cancers, in 30 stomach adenomas, in 8 carcinoid tumors, and in 4 endocrine cell carcinomas (ECCs) with assessment of gastric and/or intestinal (G/I) phenotypes in both Exo-cell and End-cell by immunohistochemistry. CgA expression was observed in 10.8% of the early and 16.4% of the advanced stomach cancers, respectively. The End-cell G/I phenotypes were in line with the Exo-cell counterparts in the CgA-positive stomach cancerous areas, and there was strong association between Cdx2 expression and the intestinal End-cell markers. All of the adenoma cases had the intestinal Exo-cell phenotypic expression, with the positive link between Exo-cell and End-cell G/I phenotypes. All stomach carcinoids had CgA expression but no expression of Exo-cell markers. In conclusion, most stomach cancers might develop from a progenitor cell specializing towards Exo-cell lineages, but some cases possessed both Exo-cell and End-cell markers with maturely differentiated phenotypes. In such cases, Exo-cell and End-cell phenotypes were found to correlate strongly, suggesting the possibility of histogenesis from “cancer stem cells”. |
Autor/es principal/es: | Takenaka, Y. Tsukamoto, T. Mizoshita, T. Ogasawara, N. Hirano, N. Otsuka, T. Ban, H. Nakamura, T. Yamamura, Y. Kaminishi, M. Tatematsu, M. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/27557 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 13 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.22, nº 3 (2007) |
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Gastric and intestinal phenotypic correlation between exocrine and endocrine components in human stomach tumors.pdf | 11,52 MB | Adobe PDF | Visualizar/Abrir |
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