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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Takenaka, Y. | es |
dc.contributor.author | Tsukamoto, T. | es |
dc.contributor.author | Mizoshita, T. | - |
dc.contributor.author | Ogasawara, N. | - |
dc.contributor.author | Hirano, N. | - |
dc.contributor.author | Otsuka, T. | - |
dc.contributor.author | Ban, H. | - |
dc.contributor.author | Nakamura, T. | - |
dc.contributor.author | Yamamura, Y. | - |
dc.contributor.author | Kaminishi, M. | - |
dc.contributor.author | Tatematsu, M. | - |
dc.date.accessioned | 2012-05-21T12:09:01Z | - |
dc.date.available | 2012-05-21T12:09:01Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/27557 | - |
dc.description.abstract | We have previously suggested that an origin of a stomach cancer is from a progenitor cell specializing toward exocrine cell (Exo-cell) lineages. To clarify whether our hypothesis is correct or not, we analyzed the expression of Exo-cell and endocrine cell (End-cell) markers in a series of lesions for comparison. We evaluated chromogranin A (CgA) expression in 37 early and 73 advanced stomach cancers, in 30 stomach adenomas, in 8 carcinoid tumors, and in 4 endocrine cell carcinomas (ECCs) with assessment of gastric and/or intestinal (G/I) phenotypes in both Exo-cell and End-cell by immunohistochemistry. CgA expression was observed in 10.8% of the early and 16.4% of the advanced stomach cancers, respectively. The End-cell G/I phenotypes were in line with the Exo-cell counterparts in the CgA-positive stomach cancerous areas, and there was strong association between Cdx2 expression and the intestinal End-cell markers. All of the adenoma cases had the intestinal Exo-cell phenotypic expression, with the positive link between Exo-cell and End-cell G/I phenotypes. All stomach carcinoids had CgA expression but no expression of Exo-cell markers. In conclusion, most stomach cancers might develop from a progenitor cell specializing towards Exo-cell lineages, but some cases possessed both Exo-cell and End-cell markers with maturely differentiated phenotypes. In such cases, Exo-cell and End-cell phenotypes were found to correlate strongly, suggesting the possibility of histogenesis from “cancer stem cells”. | es |
dc.format | application/pdf | es |
dc.format.extent | 13 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Stomach cancers | es |
dc.subject | Endocrine cells | es |
dc.subject.other | 616.3 - Patología del aparato digestivo. Odontología | es |
dc.title | Gastric and intestinal phenotypic correlation between exocrine and endocrine components in human stomach tumors | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.22, nº 3 (2007) |
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Gastric and intestinal phenotypic correlation between exocrine and endocrine components in human stomach tumors.pdf | 11,52 MB | Adobe PDF | Visualizar/Abrir |
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