Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/27533

Título: Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes
Fecha de publicación: 2007
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: 616 - Patología. Medicina clínica. Oncología
Palabras clave: Colon cancer
Mouse
Resumen: In the evolution of colon rectal cancer (CRC) the imbalance between cell proliferation and apoptosis is considered one of the prominent causes of tumor induction and/or progression. In order to establish the role of anti apoptotic proteins in colon cancer development, we studied with immunohistochemical techniques the expression of Survivin in a mouse model of colon carcinogenesis induced by 1,2-dimethylhydrazine treatment. In this mouse model Survivin was over-expressed during tumor development, showing a distribution mimicking that described in the correspondent human malignancies. We also correlated Survivin distribution with COX-2 and ß-Catenin expression patterns. The co-localization of COX-2/ß-Catenin/Survivin in the same epithelial cells in tumor samples lends credence to possible in vivo regulatory effects of COX-2 and ß- Catenin on the intracellular Survivin levels in mouse and human colon cancer.
Autor/es principal/es: Mori, F.
Piro, F.R.
Della Rocca, C.
Mesiti, G.
Giampaoli, S.
Silvestre, G.
Lazzaro, D.
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/27533
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 17
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.22, nº 1 (2007)



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