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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Mori, F. | es |
dc.contributor.author | Piro, F.R. | es |
dc.contributor.author | Della Rocca, C. | - |
dc.contributor.author | Mesiti, G. | - |
dc.contributor.author | Giampaoli, S. | - |
dc.contributor.author | Silvestre, G. | - |
dc.contributor.author | Lazzaro, D. | - |
dc.date.accessioned | 2012-05-21T12:08:19Z | - |
dc.date.available | 2012-05-21T12:08:19Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/27533 | - |
dc.description.abstract | In the evolution of colon rectal cancer (CRC) the imbalance between cell proliferation and apoptosis is considered one of the prominent causes of tumor induction and/or progression. In order to establish the role of anti apoptotic proteins in colon cancer development, we studied with immunohistochemical techniques the expression of Survivin in a mouse model of colon carcinogenesis induced by 1,2-dimethylhydrazine treatment. In this mouse model Survivin was over-expressed during tumor development, showing a distribution mimicking that described in the correspondent human malignancies. We also correlated Survivin distribution with COX-2 and ß-Catenin expression patterns. The co-localization of COX-2/ß-Catenin/Survivin in the same epithelial cells in tumor samples lends credence to possible in vivo regulatory effects of COX-2 and ß- Catenin on the intracellular Survivin levels in mouse and human colon cancer. | es |
dc.format | application/pdf | es |
dc.format.extent | 17 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Colon cancer | es |
dc.subject | Mouse | es |
dc.subject.other | 616 - Patología. Medicina clínica. Oncología | es |
dc.title | Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.22, nº 1 (2007) |
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Fichero | Descripción | Tamaño | Formato | |
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Survivin and Cyclooxygenase2 are coexpressed in human and mouse colon carcinoma and in terminally differentiated colonocytes.pdf | 5,94 MB | Adobe PDF | Visualizar/Abrir |
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