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Título: | Emerging significance of ER-coregulator PELP1-MNAR in cancer |
Fecha de publicación: | 2007 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 618 - Ginecología. Obstetricia |
Palabras clave: | Estrogen receptors Coregulators |
Resumen: | The estrogen receptors ERa and ERß have been implicated in the progression of a wide variety of cancers. The actions of ER are regulated by ER coregulator proteins, including proline-, glutamic acidand leucine-rich-protein-1 (PELP1/MNAR). PELP1 has been shown to participate in both genomic and nongenomic functions of ER. The expression and localization of PELP1/MNAR are deregulated in a wide variety of tumors and have been implicated in the development of hormonal resistance in cancer cell lines. Emerging data suggest that PELP1/MNAR interacts with many proteins and activates several oncogenes, including Src kinase, phosphotidyl inositol 3 kinase (PI3K), and signal transducers and activators of transcription 3 (STAT3). These new results suggest that PELP1/MNAR may act as an oncogene as well as cooperating with other oncogenes. Thus, PELP1/MNAR may contribute to the tumorigenic potential of cancer cells by serving as a scaffolding protein that couples various signaling complexes with ER. |
Autor/es principal/es: | Nair, S. Vadlamudi, R.K. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/27532 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.22, nº 1 (2007) |
Ficheros en este ítem:
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Emerging significance of ERcoregulator PELP1MNAR in cancer.pdf | 598,53 kB | Adobe PDF | Visualizar/Abrir |
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