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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Nair, S. | es |
dc.contributor.author | Vadlamudi, R.K. | es |
dc.date.accessioned | 2012-05-21T12:08:17Z | - |
dc.date.available | 2012-05-21T12:08:17Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/27532 | - |
dc.description.abstract | The estrogen receptors ERa and ERß have been implicated in the progression of a wide variety of cancers. The actions of ER are regulated by ER coregulator proteins, including proline-, glutamic acidand leucine-rich-protein-1 (PELP1/MNAR). PELP1 has been shown to participate in both genomic and nongenomic functions of ER. The expression and localization of PELP1/MNAR are deregulated in a wide variety of tumors and have been implicated in the development of hormonal resistance in cancer cell lines. Emerging data suggest that PELP1/MNAR interacts with many proteins and activates several oncogenes, including Src kinase, phosphotidyl inositol 3 kinase (PI3K), and signal transducers and activators of transcription 3 (STAT3). These new results suggest that PELP1/MNAR may act as an oncogene as well as cooperating with other oncogenes. Thus, PELP1/MNAR may contribute to the tumorigenic potential of cancer cells by serving as a scaffolding protein that couples various signaling complexes with ER. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Estrogen receptors | es |
dc.subject | Coregulators | es |
dc.subject.other | 618 - Ginecología. Obstetricia | es |
dc.title | Emerging significance of ER-coregulator PELP1-MNAR in cancer | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.22, nº 1 (2007) |
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Fichero | Descripción | Tamaño | Formato | |
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Emerging significance of ERcoregulator PELP1MNAR in cancer.pdf | 598,53 kB | Adobe PDF | Visualizar/Abrir |
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