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Título: | Usefulness of HPV testing in the follow-up of untreated cervical low grade lesions |
Fecha de publicación: | 2005 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::618 - Ginecología. Obstetricia |
Palabras clave: | Cervical intraepithelial neoplasia Human papillomavirus |
Resumen: | The aim of the present work was to evaluate the usefulness of high-risk human papillomavirus (HRHPV) testing for the follow-up of women with untreated low grade cervical squamous cell lesions (LSIL). For that, 412 women with a cytological diagnosis of LSIL at entry were monitored by cytology, HR-HPV testing with the Hybrid Capture II assay (HC-II) and colposcopy. Our primary endpoint was clinical progression defined by the presence of a high grade cervical intraepithelial neoplasia (CIN2 and CIN3) at the biopsy. At baseline, histological control revealed 10 CIN2 and 11 CIN3 only in the cohort of women HR-HPV+. In the follow-up, 4 CIN2 and 8 CIN3 were detected, always in the women initially HR-HPV+. Thus, the recurrence of a HR-HPV+ infection clearly selects a population at high-risk for CIN2-3. The semi-quantitative appreciation of the viral load with HC-II could not be used as a good prognostic factor for the follow-up of women with LSIL. HR-HPV testing reduces the number of cytology and colposcopy examinations in the follow-up of women aged >35 years when HPV testing is initially negative. Thus HR-HPV testing should be reserved for the follow-up of this population of women initially HR-HPV+ and proposed 6 to 12 months after the cytological diagnosis of LSIL. |
Autor/es principal/es: | Clavel, C. Bory, J.P. Caudroy, S. Lorenzato, M. Durlach, A. Graesslin, O. Quereux, C. Birembaut, P. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/22567 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 7 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.20, nº 4 (2005) |
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Usefulness of HPV testing in the.pdf | 97,06 kB | Adobe PDF | Visualizar/Abrir |
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