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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Martínez, C. | es |
dc.contributor.author | Vicente García, Vicente | es |
dc.contributor.author | Yáñez, J. | - |
dc.contributor.author | Alcaraz, M. | - |
dc.contributor.author | Castells Mora, María Teresa | - |
dc.contributor.author | Canteras, M. | - |
dc.contributor.author | Benavente-García García, Obdulio | - |
dc.contributor.author | Castillo, J. | - |
dc.date.accessioned | 2011-06-30T12:01:24Z | - |
dc.date.available | 2011-06-30T12:01:24Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/22566 | - |
dc.description.abstract | Objective: To study the effect of different phenolic compounds and red wine on pulmonary metastatic melanoma. Methods: Swiss mice were inoculated with 5x105 melanocytes B16F10 and given oral doses of diosmin, grape seed extract (GSE) and red wine. A macroscopic count was made of the metastatic nodules on the lung surface and a microscopic study by image analysis of five sections, calculating the implantation percentage and tumoral growth and invasion indices. Results: Macroscopically, the group treated with diosmin showed the greatest reduction (52%) in the number of metastatic nodules compared with the control group, which was treated with ethanol, while GSE and red wine caused decreases of 26.07 and 28.81%, respectively. Microscopically, there was a decrease in the implantation percentage after the administration of diosmin (79.4%) and red wine (20.19%), and an increase of 2.12% after the administration of GSE, all relative to the ethanol-treated control. As regards the growth index, diosmin produced a reduction of 67.44% and red wine a reduction of 20.62%, while GSE again produced an increase (25.33%). The reductions in the invasion index were 45.23, 31.65 and 17.57% with diosmin, GSE and red wine, respectively. Conclusions: Diosmin originated the greatest reduction in pulmonary metastases, both at the macroscopic and microscopic levels. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Pulmonary metastasis | es |
dc.subject | Diosmin | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.2 - Patología del aparato respiratorio | es |
dc.title | The effect of the flavonoid diosmin, grape seed extract and red wine on the pulmonary metastatic B16F10 melanoma | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.20, nº 4 (2005) |
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The effect of the flavonoid diosmin.pdf | 1,6 MB | Adobe PDF | Visualizar/Abrir |
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