Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/22563

Título: The role of fetal breathing-like movements in lung organogenesis
Fecha de publicación: 2005
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Lung hypoplasia
Microarray lesions
Resumen: In this review the recent findings concerning the role of fetal breathing-like movements (FBMs) on lung organogenesis are discussed. We first review the consequences that the lack of FBMs has on lung organogenesis and then we discuss the possible pathways that may be employed in this process. Specifically, we review the data in support of the notion that FBMs are required for the cell cycle kinetics regulation (i.e., cell proliferation and cell death) via the expression of growth factors, such as platelet derived growth factors (PDGFs) and insulin growth factors (IGFs), and thyroid transcription factor 1 (TTF-1). Moreover, the role of FBMs on biochemical differentiation of Clara cells, type I and type II pneumocytes is reviewed. Interestingly, even though type II pneumocytes are able to synthesize surfactantassociated proteins (SPs), in the complete absence of FBMs, they are unable to compile, store and release the surfactant. Similarly, in spite of the expression of some early differentiation markers, in the absence of FBMs, type I pneumocytes are unable to flatten in order to allow the gas exchange in the lung. In fact, we are currently employing the cDNA microarray analysis in search for the molecules that might be specific for the lacking functions in pneumocytes. Key words: Lung hypoplasia, Mouse embry
Autor/es principal/es: Inanlou, M.R.
Baguma-Nibasheka, M.
Kablar, B.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/22563
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 6
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.20, nº 4 (2005)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
The role of fetal breathinglike.pdf315,3 kBAdobe PDFVista previa
Visualizar/Abrir


Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.