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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Thiele, J. | es |
dc.contributor.author | Kvasnicka, H.M. | es |
dc.contributor.author | Ollig, S. | - |
dc.contributor.author | Schmitt-Gräff, A. | - |
dc.date.accessioned | 2011-06-30T12:01:11Z | - |
dc.date.available | 2011-06-30T12:01:11Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/22546 | - |
dc.description.abstract | A comparative immunohistochemical and morphometric study was performed on megakaryocytes in 20 patients presenting with initial-early stage chronic idiopathic myelofibrosis and accompanying thrombocythemia to elucidate histological features developing after hydroxyurea (HU) versus anagrelide (ANA) therapy. Representative pre-and posttreatment bone marrow biopsies were involved including the monoclonal antibody CD61 for the identification of precursor and mature stages of megakaryopoiesis. An elaborate morphometric evaluation was in keeping with a left-shifting showing a more frequent occurrence of promegakaryoblasts and microforms in both therapy groups. However, contrasting ANA, HU generated defects of differentiation consistent with significant dysplastic changes. In conclusion, concern about a possible leukemogenic capacity following long-term HU therapy is supported by our findings. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Anagrelide | es |
dc.subject | Megakaryopoiesis | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Anagrelide does not exert a myelodysplastic effect on megakaryopoiesis: a comparative immunohistochemical and morphometric study with hydroxyurea | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.20, nº 4 (2005) |
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Anagrelide does not exert a myelodysplastic effect on.pdf | 1,95 MB | Adobe PDF | Visualizar/Abrir |
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