Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/22539

Title: The role of the bone marrow microenvironment in multiple myeloma
Issue Date: 2005
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Keywords: Multiple myeloma
Osteoclast
Abstract: Multiple myeloma (MM) is a malignant disease that results from an excess of monotypic plasma cells in the bone marrow (BM). This malignancy is characterised by complex karyotypic aberrancies. In 60% of all MM there are recurrent primary translocations involving the heavy chain gene locus. The MM cells strongly interact with the BM microenvironment, which is composed of endothelial cells, stromal cells, osteoclasts, osteoblasts, immune cells, fat cells and the extracellular matrix. This interaction is responsible for the specific homing in the BM, the proliferation and survival of the MM cells, the resistance of MM cells to chemotherapy, the development of osteolysis, immunodeficiency and anaemia. New therapeutic agents target both the MM, as well as the interaction MM cell – BM microenviroment.
Primary author: De Raeve, H.
Vanderkerken, K.
Published in: Histology and histopathology
URI: http://hdl.handle.net/10201/22539
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 24
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.20, nº 4 (2005)

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