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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Gallego, R. | es |
dc.contributor.author | Pintos, E. | es |
dc.contributor.author | Garcia-Caballero, Tomas | - |
dc.contributor.author | Raghay, K. | - |
dc.contributor.author | Boulanger, L. | - |
dc.contributor.author | Beiras, Andres | - |
dc.contributor.author | Gaudreau, P. | - |
dc.contributor.author | Morel, G. | - |
dc.date.accessioned | 2011-06-30T12:00:50Z | - |
dc.date.available | 2011-06-30T12:00:50Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/22519 | - |
dc.description.abstract | Growth hormone releasing hormone receptor (GHRH-R) mRNA and protein was first localized to the anterior pituitary gland, consequent with the action of its ligand on GH synthesis and release. Subsequent studies found GHRH-R also expressed in the hypothalamus and in systemic tissues including those of the reproductive system. In the present work, we studied the distribution of GHRH-R in human reproductive system of males and females by immunohistochemical method. GHRH-R immunostaining was localized in male reproductive system: Leydig cells, Sertoli and basal germ cells of the seminiferous tubules and prostate secretory cells. GHRH-R immunostaining was also demonstrated in the ovary: oocytes, follicular cells, granulosa, thecal and corpus luteum cells. Endometrial glands, placenta and normal mammary glands also showed GHRH-R immunostaining. Our results demonstrate the localization of GHRH-R in the reproductive system, which may mediate the direct action of GHRH in these tissues. Moreover, GHRH-R was demonstrated in prostate and breast carcinomas, opening a variety of possibilities for the use of GHRH antagonists in the treatment of prostatic and mammary tumors. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Cancer | es |
dc.subject | Human | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Cellular distribution of growth hormone-releasing hormone receptor in human reproductive system and breast and prostate cancers | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.20, nº 3 (2005) |
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Cellular distribution of growth.pdf | 9,44 MB | Adobe PDF | Visualizar/Abrir |
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