Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/22518

Título: Thymidylate synthase predicts for clinical outcome in invasive breast cancer
Fecha de publicación: 2005
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Breast cancer
Resumen: Thymidylate synthase (TS) is a major target of 5-fluorouracil (5-FU) and dihydropyrimidine dehydrogenase (DPD) is a rate-limiting enzyme in the degradation of 5-FU. Whether TS or DPD could be used as valuable parameters for 5-FU sensitivity in clinical patients are largely unknown. We analyzed TS and DPD expression in breast carcinomas to evaluate the clinicopathological significance of these enzymes in patients with invasive breast cancer receiving 5-FUbased chemotherapy. A total of 197 patients with invasive ductal carcinoma were included in our study. Both the TS and DPD expression were analyzed using immunohistochemical method for all the surgical samples. Sixty-three out of 197 (31.97%) patients are positive for TS expression, and 77 out of 197 (39.09%) patients are positive for DPD expression. TS expression was not correlated with DPD expression. Patients with TS-positivity had aggressive phenotype including large tumor size, low differentiation and nodal metastasis. DPD expression is not related with phenotype or prognosis. Multivariate analysis demonstrated that TS expression was an independent prognostic factor for both disease-free and overall survival. The current study demonstrated that TS but not DPD expression was associated with both progression and prognosis in breast cancer receiving 5-FU-based chemotherapy. TS expression in the primary tumor might be useful as a predictive parameter for the efficacy of 5-FU-based chemotherapy for breast cancer.
Autor/es principal/es: Yu, Z.
Sun, J.
Zhen, J.
Zhang, Q.
Yang, Q.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/22518
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 8
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.20, nº 3 (2005)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Thymidylate synthase predicts for.pdf1,96 MBAdobe PDFVista previa

Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.