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Título: | Glycogen autophagy in the liver and heart of newborn rats. The effects of glucagon, adrenalin or rapamycin |
Fecha de publicación: | 2005 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Glucagon Adrenalin |
Resumen: | The effects of glucagon, adrenalin or rapamycin on glycogen autophagy in the liver and heart of newborn rats were studied using biochemical determinations and electron microscopy. Glucagon or adrenalin increased autophagic activity in the hepatocytes and myocardiocytes, glycogen-hydrolyzing acid glucosidase activity in the liver and heart and degradation of glycogen inside the autophagic vacuoles. Glucagon or adrenalin also increased the maltosehydrolyzing acid glucosidase activity in the liver, but not in the heart. Similar effects were produced in the newborn heart by rapamycin. These observations support previous studies suggesting that the cellular machinery which controls glycogen autophagy in the liver and heart of newborn animals, is regulated by the cyclic AMP and the mTOR pathways. |
Autor/es principal/es: | Kondomerkos, D.J. Kalamidas, Stefanos Kotoulas, Othon B. Hann, A.C. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/22513 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.20, nº 3 (2005) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Glycogen autophagy in the liver and heart of newborn.pdf | 2,33 MB | Adobe PDF | Visualizar/Abrir |
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