Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10201/22504
Twittear
Título: | Decreased density of ß1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats |
Fecha de publicación: | 2005 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Immunohistochemistry Rat liver |
Resumen: | There is some evidence that rodent hepatocarcinogenesis is accompanied by changes in the adrenergic responsiveness of liver cells to catecholamines. In this study, immunohistochemical expression of ß1-adrenergic receptors (ß1-ARs) has been examined in spontaneous and chemically induced preneoplastic and neoplastic liver lesions of female and male Fischer 344 rats. An antibody specific for ß1-AR subtype was used. The study was carried out on archival formalin-fixed and paraffin-embedded livers from rats used in a previous study of hepatocarcinogenesis. One control group given distilled water by gavage, and two experimental groups, one initiated with a single dose of diethylnitrosamine (DEN) and one initiated with DEN and continuously treated with phenobarbital (PB) were examined. Rats were sacrificed after 2, 4, 8 and 21 months of experimentation. All types of liver putative preneoplastic lesions examined (basophilic, glycogenretaining, or mixed cell foci) show a lower density of ß1- ARs than the surrounding normal liver parenchyma, either in control and in DEN-treated or DEN+PB-treated rats. No immunostaining is detectable in several altered cell foci. Hepatocellular adenomas and hepatocellular carcinomas also show a very low density of ß1-ARs, extensive areas completely devoid of ß1-ARs being mingled with areas showing a weak immunostaining. |
Autor/es principal/es: | Cardani, R. Zavanella, T. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/22504 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.20, nº 3 (2005) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Decreased density of B1adrenergic receptors in.pdf | 5,72 MB | Adobe PDF | Visualizar/Abrir |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.