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Título: | Sclerotic fibroma-like dermatofibroma: an uncommon distinctive variant of dermatofibroma |
Fecha de publicación: | 2005 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Sclerotic fibroma Immunohistochemistry |
Resumen: | Dermatofibroma (DF) is a common benign cutaneous tumor with many variants based on alterations in the morphology and composition of its diverse elements. One very infrequent type is sclerotic fibromalike DF (SF-DF). We report 7 new cases of SF-DF. In addition, their main clinicopathological and immunohistochemical features were compared with 14 unselected common DFs and with 3 sclerotic fibromas (SFs). Microscopically, the 7 cases of SF-DFs showed an unencapsulated, well-circumscribed, hypocellular central nodule with thick collagen bundles arranged in a storiform pattern with prominent clefts. The overlying epidermis was attenuated. The periphery of this nodule was more cellular with histopathologic features of common DF. The 7 SF-DFs patients were 4 women and 3 men with a mean (±SD) age of 44.8 (±15.5) years. These 7 patients were younger than those suffering from SFs [71.0 (±17.3) years; (p=0.04)] and older than those presenting common DFs [30.5 (±12.3) years; (p=0.03)]. Immunohistochemically, spindle cells in all 7 SF-DFs were negative for CD34 and CD99. On the contrary, the 3 cases of SF were positive for CD34 and CD99. All of the common DFs were negative for CD34 and only 4 (28.6%) of them were positive for CD99. In conclusion, SF-DF is an uncommon variant of DF with similar clinicopathological and immunohistochemical features. SF-DF shares certain histopathologic features with SF but they are immunophenotypically different. Therefore, both entities should be differentiated. |
Autor/es principal/es: | González-Vela, M.C. Val-Bernal, José Fernando Martino, M. González-López, M.A. García-Alberdi, E. Hermana, S. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/22502 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.20, nº 3 (2005) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Sclerotic fibromalike dermatofibroma.pdf | 5,35 MB | Adobe PDF | Visualizar/Abrir |
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