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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Uno, K. | es |
dc.contributor.author | Kuroki, M. | es |
dc.contributor.author | Hayashi, H. | - |
dc.contributor.author | Uchida, H. | - |
dc.contributor.author | Oshima, K. | - |
dc.date.accessioned | 2011-06-30T12:00:27Z | - |
dc.date.available | 2011-06-30T12:00:27Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/22492 | - |
dc.description.abstract | The purpose of this study is to investigate the expression of thrombospondin-1 (TSP-1), a multifunctional extracellular matrix protein, during reepithelialization in wounded corneas of vitamin Adeficient mice. Epithelial defects were created in the corneas of normal and Vitamin A-deficient mice with a microgrinder. Wounded corneas were stained with fluorescein and photographed for evaluation of reepithelialization. Histological examination and immunohistochemical analysis of TSP-1 expression were also performed on the specimens from wounded corneas. In vitamin A-deficient mice, re-epithelialization of the wounded corneal epithelium was significantly delayed compared with that in normal mice. TSP-1 was detectable neither in the unwounded corneal epithelium of normal mice nor in that of vitamin A-deficient mice. In normal mice, linear staining of TSP-1 was observed on the wounded corneal surface and stroma at 30 min and 8 h to 16 h, respectively, after abrasion, and this TSP-1 expression disappeared at 36 to 48 h, when reepithelialization was completed. In contrast, no TSP-1 staining was observed in the wounded corneas of vitamin A-deficient mice, except for the endothelial cells, throughout the wound healing process. Histological examination revealed a progressive increase in polymorphonuclear neutrophil infiltration in the stroma of the corneas of vitamin A-deficient mice during the healing process. These findings suggest that vitamin A may modulate the expression of TSP-1 in the corneas to accelerate the re-epithelialization of wounded corneas. | es |
dc.format | application/pdf | es |
dc.format.extent | 7 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Vitamin A deficiency | es |
dc.subject | Cornea | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::617 - Cirugía. Ortopedia. Oftalmología | es |
dc.title | Impairment of thrombospondin-1 expression during epithelial wound healing in corneas of vitamin A-deficient mice | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.20, nº 2 (2005) |
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Fichero | Descripción | Tamaño | Formato | |
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Impairment of thrombospondin1.pdf | 2,53 MB | Adobe PDF | Visualizar/Abrir |
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