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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Lo Muzio, L. | es |
dc.contributor.author | Pannone, G. | es |
dc.contributor.author | Mignogna, M.D. | - |
dc.contributor.author | Staibano, S. | - |
dc.contributor.author | Mariggiò, M.A. | - |
dc.contributor.author | Rubini, C. | - |
dc.contributor.author | Procaccini, M. | - |
dc.contributor.author | Dolcl, M. | - |
dc.contributor.author | Bufo, P. | - |
dc.contributor.author | De Rosa, G. | - |
dc.contributor.author | Piattelli, A. | - |
dc.date.accessioned | 2011-06-08T09:09:32Z | - |
dc.date.available | 2011-06-08T09:09:32Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/21626 | - |
dc.description.abstract | P-cadherin, a transmembrane molecule similar to E-cadherin involved in the cell-cell adhesion, and catenins form complexes between its cytoplasmic domain and the cytoskeleton. Five cell lines, 108 specimens of oral squamous cell carcinomas (OSCC), 9 metastasis and 10 of normal oral mucosa were examined to evaluate P-cadherin expression and cellular localization by immunohistochemistry and westernblotting. In normal oral mucosa there was a membranous expression only in basal and parabasal layers. 91 cases (84%) showed membranous/cytoplasmic positivity, whereas 17 cases (16%) were negative. In particular, while well-differentiated carcinomas showed P-cadherin upregulation, the protein was homogeneously hypo- or unexpressed in low-differentiated carcinomas. There was a statistically significant correlation between P-cadherin expression and tumour grading: G3 tumours had a lower score than G1-G2 tumours (P<0.05). When analysed for prognostic significance, patients with no P-cadherin expression (score 0) had poorer overall and diseases-free survival rates than the P-cadherin-expressing group (score 1) (P=0.0463 and P=0.0471, respectively). Western blotting analysis of cell lines and tissue samples confirmed immunohistochemical findings. When cell staining pattern of positive cases was examined, 52 cases showed a prevalent membranous pattern, while 39 had a prevalent cytoplasmic pattern. Cases with prevalent cytoplasmic staining showed high rates of lymph node metastases (P>0.05), and regional relapse (P <0.05) and poorer survival rates than the group with prevalent membranous expression (P<0.0001). An absent Pcadherin expression could constitute a hallmark of aggressive biological behaviour in oral squamous cell carcinoma. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Head and neck | es |
dc.subject | P-cadherin | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | P-cadherin expression predicts clinical outcome in oral squamous cell carcinomas | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.19, nº 4 (2004) |
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Pcadherin expression predicts clinical.pdf | 3,21 MB | Adobe PDF | Visualizar/Abrir |
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