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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Franchini, A. | es |
dc.contributor.author | Marchesini, E. | es |
dc.contributor.author | Ottaviani, E. | - |
dc.date.accessioned | 2011-06-08T09:09:03Z | - |
dc.date.available | 2011-06-08T09:09:03Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/21599 | - |
dc.description.abstract | In vivo effects of acute stress induced by corticosterone 21-acetate in male Gallus domesticus thymus are studied and the steroid actions are evaluated in terms of cell proliferation, apoptosis and cytokine response in 10- and 21-day-old chickens. Steroid treatment induced thymocyte apoptosis and cell death decreased in the cortical-medullar direction and was more evident in younger animals. 24 h after treatment, the observed effect was reversed. The mitotic activity and thymic cells containing cytokine-like molecules were also affected. Indeed, the acute stress stimulated cytokine immunoreactivity to anti-IL-1a, IL-6 and TNF- a antibodies both in epithelial cells and interdigitating cells located in medullar and cortical-medullar regions. The increased cytokine expression observed after 12 h was maintained after 24 h. The comparison between 10- and 21-day-old chickens showed a lower number of cells containing cytokine-like molecules in younger specimens. The present findings suggest that cytokines activated by acute stress in vivo could contribute to restoring immunological homeostasis and influence thymic glucocorticoid-mediated functions. | es |
dc.format | application/pdf | es |
dc.format.extent | 7 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Thymus | es |
dc.subject | Cytokines | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología | es |
dc.title | Corticosterone 21-acetate in vivo induces acute stress in chicken thymus: cell proliferation, apoptosis and cytokine responses | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.19, nº 3 (2004) |
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Fichero | Descripción | Tamaño | Formato | |
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Corticosterone 21acetate in vivo.pdf | 2,41 MB | Adobe PDF | Visualizar/Abrir |
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