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Título: | Selection events in directing B cell development |
Fecha de publicación: | 2003 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Positive selection Negative selection |
Resumen: | Homeostasis in the B cell compartment (as well as in T cells) is controlled by tightly regulated selection events. Throughout their life span, B cells are subjected to selection signals determining not only developmental progression, but also maturation and survival. It is now clear that most of these signals require the expression of B cell antigen receptor (or preB receptor) with functional signaling capacity. The administration of numerous mutations into the mouse germline enabled us to identify several checkpoints along the B cell developmental pathway, and provided us with powerful experimental tools to probe for selection events regulating developmental progression. In here, we will discuss recent studies in this field. |
Autor/es principal/es: | Seagal, J. Melamed, D. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/21433 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.18, nº 2 (2003) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Selection events in directing B cell development.pdf | 338,16 kB | Adobe PDF | Visualizar/Abrir |
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