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Título: | Review of sarcomatoid renal cell carcinoma with focus on clinical and pathobiological aspects |
Fecha de publicación: | 2003 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Sarcomatoid renal cell carcinomas Pathology |
Resumen: | In sarcomatoid renal cell carcinoma (RCC), it is generally accepted that the sarcomatoid portion is derived from metaplastic transformation of carcinoma. Sarcomatoid RCCs account for about 1-8% of all renal tumors. Macroscopically, tumors generally form encapsulated masses and show invasive growth. Sarcomatoid RCCs originate from all subtypes of RCCs, including conventional, papillary, chromophobe, and collecting duct carcinomas. With regard to the growth pattern of the sarcomatoid component, malignant fibrous histiocytomatous, fibrosarcomatous and unclassified sarcomatous patterns are frequently seen. Immunohistochemically, sarcomatoid RCCs are generally positive for AE1/AE3, epithelial membrane antigen (EMA) and vimentin and negative for desmin, actin and S-100. Little is know about genetic alterations in sarcomatoid RCCs. Further studies are therefore needed to identify the key gene involved in sarcomatoid transformation of RCCs. |
Autor/es principal/es: | Kuroda, Naoto Toi, M. Hiroi, Makoto Enzan, H. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/21425 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 5 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.18, nº 2 (2003) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Review of sarcomatoid renal cell carcinoma.pdf | 627,62 kB | Adobe PDF | Visualizar/Abrir |
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