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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Kalluri, R. | es |
dc.contributor.author | Zeisberg, M. | es |
dc.date.accessioned | 2011-06-08T09:02:16Z | - |
dc.date.available | 2011-06-08T09:02:16Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/21390 | - |
dc.description.abstract | Tubulointerstitial fibrosis is a hallmark feature of chronic renal injury. Specific therapies to control the progression of renal fibrosis towards endstage renal failure are still limited. Transforming growth factor-ß1 (TGF-ß1) has been identified as a major mediator of renal fibrosis. Recent reports have suggested that Bone Morphogenic Protein-7 (BMP-7), another member of the TGF-ß superfamily, accelerates repair of acute renal injury and ameliorates progression of chronic renal fibrosis in a variety of animal models. Interestingly, BMP-7, an endogenous molecule which is present in the normal kidney, vastly decreases its expression during renal injury. Although, the mechanism of BMP-7 action in the kidney is not yet fully understood, the idea of an endogenous molecule with reno-protective function is intriguing | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Renal fibrosis | es |
dc.subject | Tubular Epithelial Cells (TECs) | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Exploring the connection between chronic renal fibrosis and bone morphogenic protein-7 | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.18, nº 1 (2003) |
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Exploring the connection between chronic renal fibrosis.pdf | 82,07 kB | Adobe PDF | Visualizar/Abrir |
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