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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Dang, N.H. | es |
dc.contributor.author | Morimoto, C. | es |
dc.date.accessioned | 2011-05-11T10:59:06Z | - |
dc.date.available | 2011-05-11T10:59:06Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/20852 | - |
dc.description.abstract | In this review, we highlight major aspects of the biology of CD26, a dipeptidyl peptidase IV (DPPIV)-containing surface glycoprotein with multiple functions. In particular, we discuss findings demonstrating that CD26/DPPIV has an essential role in immune regulation as a T cell activation molecule and a regulator of chemokine function. We also review recent studies that identify key cellular molecules that physically associate with CD26 and the potential consequences of their interaction, including those with clinically-related implications. Furthermore, we present work suggesting a role for CD26 in the pathogenesis and behavior of selected human cancers, both solid tumors and hematological malignancies. We present recent studies that investigate the potential role of CD26 as a molecular target for novel treatment modalities for T cell lymphoid malignancies and possibly other hematological malignancies, with work involving the use of anti-CD26 monoclonal antibody, CD26-transfected cells as well as soluble CD26 molecules. | es |
dc.format | application/pdf | es |
dc.format.extent | 14 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Chemokine | es |
dc.subject | Cell cycle | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | CD26: An expanding role in immune regulation and cancer | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.17, nº 4 (2002) |
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Fichero | Descripción | Tamaño | Formato | |
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CD26 An expanding role in.pdf | 552,76 kB | Adobe PDF | Visualizar/Abrir |
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