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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Mehrabi, M.R. | es |
dc.contributor.author | Serbecic, N. | es |
dc.contributor.author | Ekmekcioglu, C. | - |
dc.contributor.author | Tamaddon, F. | - |
dc.contributor.author | Wild, T. | - |
dc.contributor.author | Plesch, K. | - |
dc.contributor.author | Sinzinger, H. | - |
dc.contributor.author | Glogar, H.D. | - |
dc.date.accessioned | 2011-05-11T10:58:58Z | - |
dc.date.available | 2011-05-11T10:58:58Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/20842 | - |
dc.description.abstract | The aim of the present study was to investigate whether the isoprostane 8-epi-PGF2a differently accumulates in semilunar valves of patients suffering from coronary heart disease (CHD, n=19) as compared to valves from healthy heart donors (controls, n=6). Sections from isolated aortic and pulmonary valves were analyzed by semiquantitative immunohistochemistry. The 8-epi-PGF2a-content was determined by using a specific radioimmunoassay. The accumulation of 8-epi-PGF2a in both valves was higher in CHD-patients in comparison to controls (Aortic valves: 36.49±11.26 % vs. 15.78±3.04 %; pulmonary valves: 46.79±9.80 % vs. 14.99±3.57 %). The results from the radioimmunoassay revealed comparable findings in both groups (CHD vs. controls: 395.95±86.09 vs. 139.50±47.46 pg/mg protein in the aortic valves and 430.47±76.30 vs. 147.33±53.84 pg/mg protein in pulmonary valves). Pulmonary valves seem to be more susceptible to oxidative stress than aortic valves as evidenced by a higher accumulation of 8-epi-PGF2a in CHD patients. Considering the data presented in this study, we suggest that 8-epi-PGF2a is a valuable indicator of oxidative injury in human semilunar valve | es |
dc.format | application/pdf | es |
dc.format.extent | 7 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Atherosclerosis | es |
dc.subject | Coronary heart disease | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::612 - Fisiología | es |
dc.title | Enhanced accumulation of the isoprostane, 8-epi-PGF2a, in human aortic and pulmonary valves of patients with coronary heart disease | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.17, nº 4 (2002) |
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Fichero | Descripción | Tamaño | Formato | |
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Enhanced accumulation of the isoprostane.pdf | 524,25 kB | Adobe PDF | Visualizar/Abrir |
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