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Title: Time-dependent effects of maternal continuous propranolol on fetal lung development in rats
Issue Date: 2002
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: CDU::5 - Ciencias puras y naturales::57 - Biología
Keywords: Lung development
Beta blockade
Abstract: Previous studies have demonstrated a role for the beta-adrenergic system in the maturation of the fetal alveolar epithelium. Chronic blockade of beta-adrenergic binding sites has been shown to adversely ef f e c t p hysiologic and biochemical indices of fetal lung maturation. In the present study timed-pregnant female Sprague-Dawley rats were treated with a continuous 0.5 mg/hr dose of propranolol HCl, or saline, via an osmotic pump. The treatment periods were days 18-21, or 20-23 of gestation. Fetal body weights were obtained, and the morphology of the fetal lungs studied by light and electron microscopy. Cytoplasmic volume densities of lamellar inclusion bodies and glycogen within d eveloping type II alveolar epithelial cells were also determined. In addition, total phospholipids (as phosphorus) and glycogen content were determined b i o c h e m i c a l l y. The fetuses from females treated from day 20-23 demonstrated no differences between salinetreated and propranolol-treated groups, in either fetal weight or the morphologic appearance of the developing lung. In contrast, the fetuses from mothers treated from day 18-21 with propranolol were significantly smaller, and their lungs appeared less mature than saline-treated counterparts. The glycogen content of developing type II alveolar epithelial cells was significantly more abundant (as judged by stereologic and biochemical analyses) in the propranolol-treated fetuses. In addition, total phospholipids were decreased in the propranolol-treated 21-day fetuses. The results of the present study suggest that the development of the alveolar epithelium is s e n s i t ive to continuous beta-adrenergic blockade by propranolol during a critical time late in gestation.
Primary author: Smith, Dennis M.
Sommers Smith, Sally K.
Published in: Histology and histopathology
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 10
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.17, nº 2 (2002)

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