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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Smith, Dennis M. | es |
dc.contributor.author | Sommers Smith, Sally K. | es |
dc.date.accessioned | 2011-05-11T10:58:03Z | - |
dc.date.available | 2011-05-11T10:58:03Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/20779 | - |
dc.description.abstract | Previous studies have demonstrated a role for the beta-adrenergic system in the maturation of the fetal alveolar epithelium. Chronic blockade of beta-adrenergic binding sites has been shown to adversely ef f e c t p hysiologic and biochemical indices of fetal lung maturation. In the present study timed-pregnant female Sprague-Dawley rats were treated with a continuous 0.5 mg/hr dose of propranolol HCl, or saline, via an osmotic pump. The treatment periods were days 18-21, or 20-23 of gestation. Fetal body weights were obtained, and the morphology of the fetal lungs studied by light and electron microscopy. Cytoplasmic volume densities of lamellar inclusion bodies and glycogen within d eveloping type II alveolar epithelial cells were also determined. In addition, total phospholipids (as phosphorus) and glycogen content were determined b i o c h e m i c a l l y. The fetuses from females treated from day 20-23 demonstrated no differences between salinetreated and propranolol-treated groups, in either fetal weight or the morphologic appearance of the developing lung. In contrast, the fetuses from mothers treated from day 18-21 with propranolol were significantly smaller, and their lungs appeared less mature than saline-treated counterparts. The glycogen content of developing type II alveolar epithelial cells was significantly more abundant (as judged by stereologic and biochemical analyses) in the propranolol-treated fetuses. In addition, total phospholipids were decreased in the propranolol-treated 21-day fetuses. The results of the present study suggest that the development of the alveolar epithelium is s e n s i t ive to continuous beta-adrenergic blockade by propranolol during a critical time late in gestation. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Lung development | es |
dc.subject | Beta blockade | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología | es |
dc.title | Time-dependent effects of maternal continuous propranolol on fetal lung development in rats | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.17, nº 2 (2002) |
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Timedependent effects of maternal continuous.pdf | 2,68 MB | Adobe PDF | Visualizar/Abrir |
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