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Título: | Tetranectin expression in gastric adenocarcinomas |
Fecha de publicación: | 2002 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.3 - Patología del aparato digestivo. Odontología |
Palabras clave: | Adenocarcinoma Stomach |
Resumen: | A i m s : The aim was to analyze the immunohistochemical localization of tetranectin in gastric adenocarcinomas and the adjacent tissues of the wall of the stomach. Methods and results: Forty cases of gastric adenocarcinomas were stained by the indirect immunoperoxidase method. Of the ten cases of mucinous signet ring cell carcinomas 5 showed high, 3 moderate and 2 low tetranectin expression. Of the ten cases of well-differentiated intestinal type adenocarcinomas (ITA) 4 showed moderate regional, 3 l ow regional and 3 nega t ive tetranectin expression. Of the ten cases of moderately-differentiated ITA 3 showed moderate regional, 4 low regional and 3 nega t ive tetranectin expression. Of the ten cases of poorlyd i fferentiated ITA 4 showed focal low and 6 nega t ive tetranectin expression. Overall, the mucinous signet ring carcinomas showed significantly higher tetranectin expression compared to ITA (c2=3.95, p<0.05). In contrast, no significant relationship was found between tetranectin expression and the degree of differentiation in I TA (c2=2.5, p>0.05). In all cases, the perineoplastic desmoplastic reactive stroma showed high expression of tetranectin intra- and extracellularly. The mast cells and goblet cells in the areas of intestinal metaplasia showed high tetranectin expression. C o n c l u s i o n s : This study s h ows that: a) tetranectin is produced and deposited extracellularly in the desmoplastic peritumoral stroma of i n filtrating gastric adenocarcinomas; b) tetranectin is more highly expressed by the mucinous signet ring cell carcinomas compared to ITA; and c) the amount of tetranectin produced by the ITA is unrelated with the degree of tumor differentiation. |
Autor/es principal/es: | Arvanitis, D. Kamper, E.F. Kopeikina, L. Stavridou, A. Sgantzos, M. Kallioras, V. Athanassiou, E.D. Kanavaros, Panagiotis |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/20772 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 5 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.17, nº 2 (2002) |
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Tetranectin expression in gastric adenocarcinomas.pdf | 91,56 kB | Adobe PDF | Visualizar/Abrir |
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