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Título: | Genetic and epigenetic alterations of tumor suppressor and tumor-related genes in gastric cancer |
Fecha de publicación: | 2002 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Gastric cancer Methylation |
Resumen: | Both genetic and epigenetic alterations of tumor suppressor and tumor-related genes involved in the pathogenesis of gastric cancer are reviewed here, and molecular pathways of gastric carcinogenesis are proposed. Gastric carcinomas are believed to evolve from native gastric mucosa or intestinal metaplastic mucosa that undergoes genetic and epigenetic alterations involving either the suppressor pathway (defects in tumor suppressor genes) or mutator pathway (defects in DNA mismatch repair genes). Methylation of E - c a d h e r i n in native gastric mucosa results in undifferentiated carcinomas (suppressor pathway), while methylation of hMLH1 results in differentiated foveolartype carcinomas (mutator pathway). The majority of d i fferentiated gastric carcinomas however, arise from intestinal metaplastic mucosa and exhibit structural alterations of tumor suppressor genes, especially p 5 3. They appear to be related to chronic injury, perhaps due to Helicobacter pylori infection. Approximately 20% of differentiated carcinomas (ordinary-type) have evidence of mutator pathway tumorigenesis. Mutations of E - c a d h e r i n are mainly involved in the progression of d i fferentiated carcinomas to undifferentiated tumors. The molecular pathways of gastric carcinogenesis depend on the histological background, and gastric carcinomas show distinct biological behaviors as a result of discernible cellular genetic and epigenetic alterations. |
Autor/es principal/es: | Tamura, G. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/20735 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 7 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.17, nº 1 (2002) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Genetic and epigenetic alterations of tumor.pdf | 128,19 kB | Adobe PDF | Visualizar/Abrir |
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