Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/20694

Título: Effects of orexins A and B on the secretory and proliferative activity of immature and regenerating rat adrenal glands
Fecha de publicación: 2001
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Orexins
Orexin receptors
Resumen: Orexins A and B are two hypothalamic peptides, involved in the central regulation of feeding, which act through two receptor subtypes, named OXIR and OX2R. OXIR is selective for orexin-A, and OX2R binds both orexins. We have investigated the effects of three subcutaneous injections of 10 nmollkg body weight of orexins on the secretion and proliferative activity of immature (20-day-old) and regenerating rat adrenal cortex. The presence of both OXIR and OX2R mRNAs has been detected by reverse transcriptionpolymerase chain reaction in adult, immature and regenerating adrenals. Orexin-A increased corticosterone plasma concentration in immature rats, but not in animals with regenerating adrenals. Both orexins raised metaphase index (%o of metaphase-arrested cells) in immature rat adrenals, orexin-B being more effective than orexin-A. In contrast, both orexins equipotently lowered adrenal metaphase index at day 5 (but not day 8) of adrenal regeneration. We conclude that orexins (1) stimulate secretion and proliferative activity of immature rat adrenals, acting through OXIR and OX2R, respectively; and (2) do not affect secretion, but inhibit proliferative activity of regenerating adrenals, mainly via the activation of OX2R.
Autor/es principal/es: Malendowicz, L.K.
Jedrzejczak, N.
Belloni, A. S.
Tretjer, M.
Hochol, A.
Nussdorfer, G.G.
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/20694
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 5
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.16, nº 3 (2001)



Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.