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Título: | Effects of orexins A and B on the secretory and proliferative activity of immature and regenerating rat adrenal glands |
Fecha de publicación: | 2001 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Orexins Orexin receptors |
Resumen: | Orexins A and B are two hypothalamic peptides, involved in the central regulation of feeding, which act through two receptor subtypes, named OXIR and OX2R. OXIR is selective for orexin-A, and OX2R binds both orexins. We have investigated the effects of three subcutaneous injections of 10 nmollkg body weight of orexins on the secretion and proliferative activity of immature (20-day-old) and regenerating rat adrenal cortex. The presence of both OXIR and OX2R mRNAs has been detected by reverse transcriptionpolymerase chain reaction in adult, immature and regenerating adrenals. Orexin-A increased corticosterone plasma concentration in immature rats, but not in animals with regenerating adrenals. Both orexins raised metaphase index (%o of metaphase-arrested cells) in immature rat adrenals, orexin-B being more effective than orexin-A. In contrast, both orexins equipotently lowered adrenal metaphase index at day 5 (but not day 8) of adrenal regeneration. We conclude that orexins (1) stimulate secretion and proliferative activity of immature rat adrenals, acting through OXIR and OX2R, respectively; and (2) do not affect secretion, but inhibit proliferative activity of regenerating adrenals, mainly via the activation of OX2R. |
Autor/es principal/es: | Malendowicz, L.K. Jedrzejczak, N. Belloni, A. S. Tretjer, M. Hochol, A. Nussdorfer, G.G. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/20694 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 5 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.16, nº 3 (2001) |
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Effects of orexins A and B on the secretory and proliferative activity of immature and regenerating rat adrenal glands.pdf | 2,81 MB | Adobe PDF | Visualizar/Abrir |
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