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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Malendowicz, L.K. | es |
dc.contributor.author | Jedrzejczak, N. | es |
dc.contributor.author | Belloni, A. S. | - |
dc.contributor.author | Tretjer, M. | - |
dc.contributor.author | Hochol, A. | - |
dc.contributor.author | Nussdorfer, G.G. | - |
dc.date.accessioned | 2011-05-11T10:56:36Z | - |
dc.date.available | 2011-05-11T10:56:36Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/20694 | - |
dc.description.abstract | Orexins A and B are two hypothalamic peptides, involved in the central regulation of feeding, which act through two receptor subtypes, named OXIR and OX2R. OXIR is selective for orexin-A, and OX2R binds both orexins. We have investigated the effects of three subcutaneous injections of 10 nmollkg body weight of orexins on the secretion and proliferative activity of immature (20-day-old) and regenerating rat adrenal cortex. The presence of both OXIR and OX2R mRNAs has been detected by reverse transcriptionpolymerase chain reaction in adult, immature and regenerating adrenals. Orexin-A increased corticosterone plasma concentration in immature rats, but not in animals with regenerating adrenals. Both orexins raised metaphase index (%o of metaphase-arrested cells) in immature rat adrenals, orexin-B being more effective than orexin-A. In contrast, both orexins equipotently lowered adrenal metaphase index at day 5 (but not day 8) of adrenal regeneration. We conclude that orexins (1) stimulate secretion and proliferative activity of immature rat adrenals, acting through OXIR and OX2R, respectively; and (2) do not affect secretion, but inhibit proliferative activity of regenerating adrenals, mainly via the activation of OX2R. | es |
dc.format | application/pdf | es |
dc.format.extent | 5 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Orexins | es |
dc.subject | Orexin receptors | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Effects of orexins A and B on the secretory and proliferative activity of immature and regenerating rat adrenal glands | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.16, nº 3 (2001) |
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Effects of orexins A and B on the secretory and proliferative activity of immature and regenerating rat adrenal glands.pdf | 2,81 MB | Adobe PDF | Visualizar/Abrir |
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