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Título: | Immunohistochemical profile of galectin-8 expression in benign and malignant tumors of epithelial, mesenchymatous and adipous origins, and of the nervous system |
Fecha de publicación: | 2001 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Immunohistochemistry Lectins |
Resumen: | This study aims to investigate whether the immunohistochemical expression of galectin-8 could be used as a diagnostic marker in tumor tissues of various histogenetic origins including specimens from epithelial (n=145), mesenchymatous (n=16), adipous (n=10) and central and peripheral nervous system (n=25) tissue, and 4 mesotheliomas. Immunohistochemical reactions were carried out with a polyclonal anti-galectin-8 antibody and histological slides from tissues derived from the files of the Laboratory of Anatomopathology of University Erasmus Hospital, Brussels. Formalin-fixed paraffinembedded tissues of 45 normal cases as well as 41 benign and 114 malignant tumors were studied. Marked decreases in immunohistochemical galectin-8 expression were obsewed in colon (p=0.001), pancreas (p=0.007), liver (p=0.0008), skin (p=0.002) and larynx (p=0.02) tissue when comparing malignant tissue to normal tissue andlor benign tumors. The reverse relationship was observed for breast tissue (p=0.007). No statistically significant differences (p>0.05) were detected when comparing normal tissue andlor benign to malignant tumors in lung, bladder, kidney, prostate and stomach tissue. Significant galectin-8 expression was also measured in non-epithelial tissue including tumors of the central and peripheral nervous system as well as in skeletal muscle and mesotheliomas. Immunohistochemical monitoring of galectin-8 thus reveals an organtype- dependent regulation of expression upon malignant transformation of various tissue types of epithelial origin. This observation will prompt further studies to 0ffprin.int requests to: Roberl Kiss, Ph.D., Laboratory of Histopathology, Faculty of Medicine - Free University of Brussels, 808 route de Lennik - 1070 Brussels, Belgiurn. Fax: 322 555 62 85. e-rnail: rkiss@ulb.ac.be delineate any relationship with prognosis |
Autor/es principal/es: | Danguy, A. Rorive, S. Decaestecker, C. Bronckart, Y. Kaltner, H. Hadari, Y.R. Goren, R. Zich, Y. Petein, M. Salmon, I. Gabius, H.J. Kiss, R. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/20688 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.16, nº 3 (2001) |
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Fichero | Descripción | Tamaño | Formato | |
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Immunohistochemical profile of galectin8 expression in benign and malignant tumors of epithelial mesenchymatous.pdf | 4,76 MB | Adobe PDF | Visualizar/Abrir |
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