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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Danguy, A. | es |
dc.contributor.author | Rorive, S. | es |
dc.contributor.author | Decaestecker, C. | - |
dc.contributor.author | Bronckart, Y. | - |
dc.contributor.author | Kaltner, H. | - |
dc.contributor.author | Hadari, Y.R. | - |
dc.contributor.author | Goren, R. | - |
dc.contributor.author | Zich, Y. | - |
dc.contributor.author | Petein, M. | - |
dc.contributor.author | Salmon, I. | - |
dc.contributor.author | Gabius, H.J. | - |
dc.contributor.author | Kiss, R. | - |
dc.date.accessioned | 2011-05-11T10:56:29Z | - |
dc.date.available | 2011-05-11T10:56:29Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/20688 | - |
dc.description.abstract | This study aims to investigate whether the immunohistochemical expression of galectin-8 could be used as a diagnostic marker in tumor tissues of various histogenetic origins including specimens from epithelial (n=145), mesenchymatous (n=16), adipous (n=10) and central and peripheral nervous system (n=25) tissue, and 4 mesotheliomas. Immunohistochemical reactions were carried out with a polyclonal anti-galectin-8 antibody and histological slides from tissues derived from the files of the Laboratory of Anatomopathology of University Erasmus Hospital, Brussels. Formalin-fixed paraffinembedded tissues of 45 normal cases as well as 41 benign and 114 malignant tumors were studied. Marked decreases in immunohistochemical galectin-8 expression were obsewed in colon (p=0.001), pancreas (p=0.007), liver (p=0.0008), skin (p=0.002) and larynx (p=0.02) tissue when comparing malignant tissue to normal tissue andlor benign tumors. The reverse relationship was observed for breast tissue (p=0.007). No statistically significant differences (p>0.05) were detected when comparing normal tissue andlor benign to malignant tumors in lung, bladder, kidney, prostate and stomach tissue. Significant galectin-8 expression was also measured in non-epithelial tissue including tumors of the central and peripheral nervous system as well as in skeletal muscle and mesotheliomas. Immunohistochemical monitoring of galectin-8 thus reveals an organtype- dependent regulation of expression upon malignant transformation of various tissue types of epithelial origin. This observation will prompt further studies to 0ffprin.int requests to: Roberl Kiss, Ph.D., Laboratory of Histopathology, Faculty of Medicine - Free University of Brussels, 808 route de Lennik - 1070 Brussels, Belgiurn. Fax: 322 555 62 85. e-rnail: rkiss@ulb.ac.be delineate any relationship with prognosis | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Immunohistochemistry | es |
dc.subject | Lectins | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Immunohistochemical profile of galectin-8 expression in benign and malignant tumors of epithelial, mesenchymatous and adipous origins, and of the nervous system | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.16, nº 3 (2001) |
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Immunohistochemical profile of galectin8 expression in benign and malignant tumors of epithelial mesenchymatous.pdf | 4,76 MB | Adobe PDF | Visualizar/Abrir |
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