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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Kusakabe, T. | es |
dc.contributor.author | Matsuda, H. | es |
dc.contributor.author | Hirakawa, H. | - |
dc.contributor.author | Hayashida, Y. | - |
dc.contributor.author | Ichikawa, T. | - |
dc.contributor.author | Kawakami, T. | - |
dc.contributor.author | Takenaka, T. | - |
dc.date.accessioned | 2011-02-22T11:22:40Z | - |
dc.date.available | 2011-02-22T11:22:40Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/19365 | - |
dc.description.abstract | The distribution and ultrastructural characteristics of calbindin D-28k immunoreactive nerve fibers were examined in the carotid body of the normoxic control rats by light and electron microscopy, and the abundance of calbindin D-28k fibers in the carotid body was compared in normoxic and chronically hypoxic rats (10% O2 and 3.0-4.0% CO2 for 3 months). Calbindin D-28k immunoreactivity was recognized in nerve fibers within the carotid body. Calbindin D-28k immunoreactive nerve fibers appeared as thin processes with many varicosities. They were distributed around clusters of glomus cells, and around blood vessels. Immunoelectron microscopy revealed that the calbindin D-28k immunoreactive nerve terminals are in close apposition with the glomus cells, and membrane specialization is visible in some terminals. Some densecored vesicles in the glomus cells were aggregated in this contact region. The chronically hypoxic carotid bodies were found to be enlarged several fold, and a relative abundance of calbindin D-28k fibers was lesser than in the normoxic carotid bodies. When expressed by the density of varicosities per unit area of the parenchyma, the density of calbindin D-28k fibers associated with the glomus cells in chronically hypoxic carotid bodies was decreased by 70%. These immunohistochemical findings indicate a morphological basis for involvement of calcium binding protein in the neural pathway that modulates carotid body chemoreception. | es |
dc.format | application/pdf | es |
dc.format.extent | 7 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Carotid body | es |
dc.subject | Hypoxia | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Calbindin D-28k immunoreactive nerve fibers in the carotid body of normoxic and chronically hypoxic rats | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.15, nº 4 (2000) |
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Calbindin D28k immunoreactive nerve fibers in the carotid body of normoxic and chronically hypoxic rats.pdf | 504,09 kB | Adobe PDF | Visualizar/Abrir |
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